Abstract
A concise, rapid and highly efficient method for the one-pot synthesis of novel pyridopyrimidine derivatives has been demonstrated by the “four-component” domino reaction of aromatic aldehyde, benzenesulfonyl acetonitrile, 1,1-dimethylthio-2-nitroethylene and 1,3-propanediamine, using piperidine as a catalyst and ethanol as solvent under microwave irradiation. This methodology was established with many advantages, including higher reaction yields, broad substrate scopes, experimental simplicity, short time and utility of easily available starting materials. The synthesized compounds are confirmed by 1H NMR, IR and HR-ESI-MS.