An efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes leading to α-halomethyl ketones

Abstract

A highly efficient heterogeneous gold(I)-catalyzed hydration of haloalkynes has been developed that proceeds smoothly under mild and neutral conditions and provides a general and practical route for the synthesis of a variety of α-halomethyl ketones with high atom-economy, excellent yield, and recyclability of the gold(I) catalyst. The presented method delivers an attractive alternative to classical α-halogenation of ketones.

Graphical Abstract

Keywords:

• Gold
• hydration
• haloalkyne
• MCM-41
• heterogeneous catalysis

Additional information

Funding

We thank the National Natural Science Foundation of China (No. 21462021), the Natural Science Foundation of Jiangxi Province of China (No. 20161BAB203086), and Key Laboratory of Functional Small Organic Molecule, Ministry of Education (No. KLFS-KF-201704) for financial support.