Efficient and selective microwave-assisted copper-catalyzed synthesis of quinazolinone derivatives in aqueous

Abstract

Microwave-assisted copper-catalyzed cascade reactions between 2-halobenzoic acids and amidines to synthesize quinazolinone derivatives in water are reported. A variety of target products were obtained in good to excellent yields up to 94%. Its application was performed by the synthesis of 4-(1H-benzo[d]imidazol-2-ylthio)-6-methoxypteridine, which displayed significant anti-proliferation effect.

GRAPHIC ABSTRACT

Keywords:

• Catalysis
• copper
• microwave
• quinazolinone
• water

Additional information

Funding

We appreciate the Fujian Provincial Research Foundation (Nos. 2016Y9051, 2016J01686, 2016J01372, 2017J01820) for financial support.