PEG-400 promoted a simple, efficient, and recyclable catalyst for the one-pot eco-friendly synthesis of functionalized isoxazole substituted pyrroles in aqueous medium

Abstract

A simple, efficient, and green approach for the synthesis of novel isoxazolyl pyrroles have been described by a one-pot reaction of isoxazolyl enamino esters and nitroolefins using H₂O as a reaction medium and polyethylene glycol (PEG-400) as a promoter. This method demonstrates to be a simple, efficient, and environmentally benign in terms of metal, base free, less-reaction time, excellent yields, wide substrates scope, and PEG-400 can be recovered and reused. Most important of all, this reaction process is green.

GRAPHICAL ABSTRACT

Keywords:

• Green chemistry
• isoxazolyl pyrroles
• one-pot synthesis
• PEG-400

Acknowledgments

RP thanks the Department of chemistry JNTU-H and Mylan Laboratories for providing research facilities. We are grateful to Dr. M. N. Reddy for his helpful discussions.

Additional information

Funding

This work was financially supported by the Department of Science and Technology (DST), New Delhi, for supporting this work [IFA13-CH-108 and Grant number GAP-0439].