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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 48, 2018 - Issue 24
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Articles

Total synthesis of cytotoxic pyranone B

, &
Pages 3133-3138 | Received 02 Jul 2018, Published online: 22 Nov 2018
 

Abstract

The first stereoselective total synthesis of cytotoxic diacetylene pyranone B is described. The key steps involved in the synthesis are base-induced elimination protocol to generate the chiral acetylenic alcohol and selective cross-coupling of unsymmetrical terminal acetylenes.

Graphical Abstract

Additional information

Funding

U.M.G., S.K. thanks UGC and CSIR, New Delhi, India for financial assistance in the form of fellowships.

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