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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 4
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Articles

Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction

Waléria F. Rabêlo Department of Chemistry, Federal University of São Carlos - UFSCar , São Carlos, São Paulo, Brazil; View further author information
&
Radell Echemendía Department of Chemistry, Federal University of São Carlos - UFSCar , São Carlos, São Paulo, Brazil; ; Center for Natural Products Research, Faculty of Chemistry, University of Havana , La Habana, CubaCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-5310-2068View further author information
ORCID Icon
Pages 515-521 | Received 30 Aug 2018, Accepted 19 Nov 2018, Published online: 19 Feb 2019
 
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Abstract

In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.

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Acknowledgments

We are grateful to the Federal University of São Carlos (UFSCar).

Additional information

Funding

This work was supported by the CNPq under [Grant 141770/2015-5].

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