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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 4
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Articles

Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction

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Pages 515-521 | Received 30 Aug 2018, Accepted 19 Nov 2018, Published online: 19 Feb 2019
 

Abstract

In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.

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Acknowledgments

We are grateful to the Federal University of São Carlos (UFSCar).

Additional information

Funding

This work was supported by the CNPq under [Grant 141770/2015-5].

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