Preparation of a simple biocompatible magnetite@citric acid: An efficient reusable solid acid catalyst for the rapid synthesis of antipyrine Schiff’s bases and study of their radical scavenging potential

Abstract

Citric acid immobilized magnetic nanoparticles (MNPs@CA) have been synthesized and used for the preparation of bio-important antipyrine (1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) derived Schiff’s bases (3a-k) in lesser reaction time with very high yield under ultrasonication. The catalyst was characterized by FT-IR, powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM), and thermogravimetric analysis (TGA). The functionalized nanoparticles were easily separated using an external magnet during work-up procedure and show excellent reusability upto 8 cycles without any significant loss in catalytic activity. All the synthesized compounds (3a-k) were screened by DPPH (2,2-diphenyl-1-picrylhydrazyl) method with respect to ascorbic acid for their antioxidant activity and some of them gave promising results.

Graphical Abstract

Keywords:

• Magnetite@citric acid nanoparticles
• Schiff’s base
• reusable
• antioxidant activity
• 4-amino antipyrine

Acknowledgements

Authors are thankful to Materials Research Centre, MNIT Jaipur for providing spectral analysis facilities.

Additional information

Funding

M. Kumari acknowledge to Department of Science and technology (DST), India, for providing JRF under INSPIRE fellowship scheme (IF140506). One of the author Y. Jain is grateful to MNIT Jaipur for providing financial assistance.