A synthesis and biological screening of newly substituted 9-methyl-6-aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridines using chloranil

Abstract

An effective, mild, and convenient method for the synthesis of 10 new substituted 9-methyl-6-aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridines (5a–j) by the oxidation of the corresponding 2-(2-ethylidenehydrazinyl)-3-aryl-1,8-naphthyridines (4a–j) using chloranil under conventional method has been described. The structures of synthesized compounds (5a–j) were established on the basis of their elemental analysis and spectral (IR, Mass, ¹³C- and¹H-NMR) data. The new compounds were synthesized with the objective of studying their antibacterial activity. The reaction will be characterized by easy workup, good efficacy, simple purification of the products, and availability of catalyst.

Graphical Abstract

Keywords:

• Acetaldehyde
• antibacterial activity
• chloranil
• fused 1,2,4-triazoles
• fused 1,8-naphthyridines

Acknowledgments

The authors are thankful to the Head, Department of Chemistry and Osmania University for providing laboratory facilities and Directors, CFRD-OU & IICT-Hyderabad for providing spectral and analytical data. I wish to thank UGC, New Delhi for the award of Senior Research Fellowship to Dharavath Ravi.