Abstract
This study reports the synthesis of a methoxy-substituted 2,6-di(1,8-naphthyridin-2-yl)pyridine using Friedländer methodology. The functionalization at the 4-carbon of the methoxy-substituted derivative was confirmed by X-ray structural analysis. Finally, the methyl ether protecting group was cleaved to obtain 2,6-di(1,8-naphthyridin-2-yl)pyridine-4-ol. Using the compounds, coordination behavior to ruthenium(II) center was also examined.
Graphical Abstract
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Acknowledgments
We would like to thank Dr. Kyeonga Inomata at Tohoku University for HRMS measurements of 2d and Rigaku Corporation for the X-ray measurement of the Ru-complex.