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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 14
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Articles

Triarylimidazo[1,2-a]pyridine-8-carbonitriles: solvent-free synthesis and their anti-cancer evaluation

Annah GuptaDepartment of Chemistry, University of Jammu, Jammu, India;
,
Sonakshi SasanDepartment of Chemistry, University of Jammu, Jammu, India;
,
Avneet KourCancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu, India;
,
Nargis NelofarDepartment of Zoology, G.D.C, Jammu, India
,
Dilip Manikrao MondheCancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicines, Jammu, India;
&
Kamal K. KapoorDepartment of Chemistry, University of Jammu, Jammu, India; Correspondence[email protected]
Pages 1813-1822 | Received 12 Jan 2019, Published online: 06 May 2019
 
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Abstract

In this study, we have presented the synthesis of novel 2,5,7-triarylimidazo[1,2-a]pyridine-8-carbonitriles from 2-amino-4,6-diarlypyridine-3-carbonitrile and nitrostyrene using FeCl3 (20 mol%) as Lewis acid under solvent-free conditions. A library of compounds with diverse substitutions have also been synthesized and screened for in-vitro anti-cancer activity against various cell lines such as A549 (Lung), HCT-116 (Colon), SW-620 (Colon), and MIAPACA (Pancreas).

Graphical Abstract

Acknowledgments

The authors are thankful to Department of Chemistry, University of Jammu for providing all necessary facilities and Department of Science and Technology, Government of India, New Delhi for NMR facility under PURSE and INSPIRE fellowship [AG].

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