Innovative approach for the synthesis of N-substituted amides from nitriles and alcohols using propylphosphonic anhydride (T3P^®) under solvent-free conditions

Abstract

Novel and convenient methodology for the construction of N-substituted amide derivatives have been developed from nitriles and alcohols using propylphosphonic anhydride (T3P^®). This methodology is an alternate approach to the synthesis of amides via Ritter reaction, which is one of the classical methods for the synthesis of N-substituted amides from nitriles and alcohols. In this approach, first T3P^® activates the alcohol which is then attacked by nitrile to form N-substituted amides. This methodology can also apply for the synthesis of benzhydryl ether. This developed protocol is one of the novel applications of T3P^®.

Graphical Abstract

Keywords:

• Nitriles
• N-substituted amides
• propylphosphonic anhydride (T3P^®)
• solvent-free condition

Acknowledgements

We thank NMR Facility, Institute of Excellence, University of Mysore, Manasagangotri, Mysuru, India for spectral data.

Additional information

Funding

Financial support from the DBT Glue grant No.BT/PR23078/MED/29/1253/2017 dated-22/03/2018 and VGST [K-FIST (L1)] grant No.KSTePS/VGST/K-FIST (L1)/2017-18/GRD-681/79/2018-2019 dated-17/09/2018 is gratefully acknowledged.