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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 20
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Articles

Antioxidant activity of some N-heterocycles derived from 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide

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Pages 2651-2661 | Received 09 Apr 2019, Published online: 13 Aug 2019
 

Abstract

Efficient and convenient synthesis of coumarin derivatives was accomplished via reactions of 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinecarbothioamide with some carbon electrophiles, e.g. maleic anhydride, dimethyl acetylenedicarboxylate, 1,2-dichloroethane, 3′-nitro-w-bromoacetophenone, N-(4-acetylphenyl)-2-chloroacetamide, ethyl cyanoacetate/3-chlorobenzaldehyde and acetylacetone to construct some N-heterocycles such as thiazolidine, thiazole, pyrimidine and pyrazolone derivatives. The structures of all synthesized products were substantiated from their analytical and spectral data. The antioxidant activities of the synthesized compounds were examined.

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