Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies

Abstract

A facile and highly efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives has been developed by the condensation of anthranilamide with aldehydes using sulfonic acid functionalized l-Proline@Fe₃O₄ nanoparticles as a catalyst. The advantages of this protocol are easy recovery and reusability of the catalyst besides simple work-up procedure and short reaction time. In addition, the anthelmintic activities of some selective compounds were investigated and it was found that 2-phenyl-2,3-dihydroquinazolin-4(1H)-one exhibited profound anthelmintic activity against two helminth models.

Graphical Abstract

Keywords:

• 2,3-Dihydroquinazolin-4(1H)-ones
• anthranilamide
• chlorosulfonic acid
• functionalized organo-nanocatalyst
• magnetic nanocatalyst

Acknowledgments

The authors acknowledge SAIF-NEHU, Department of chemistry, NEHU, Dr L. Robindro Singh, Department of Nanotechnology for Powder XRD data analysis. The authors also acknowledge the CIF, IIT Guwahati for VSM and FE-SEM analysis.

Additional information

Funding

The authors acknowledge the financial support from DST-SERB [sanctioned no.: EEQ/2016/000646].