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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 20
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Articles

Total synthesis of pandangolide 1 proposed structure*

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Pages 2709-2716 | Received 25 Apr 2019, Published online: 16 Jul 2019
 

Abstract

A synthetic strategy for the proposed structure of the pandangolide 1 is disclosed starting from 1,3-propane diol in 18-steps. Sharpless asymmetric dihydroxylation, Keck allylation, Yamaguchi esterification, and Grubbs ring closing metathesis were the key steps in the synthesis.

Graphical Abstract

Additional information

Funding

CRR is grateful to Council of Scientific and Industrial Research (CSIR), New Delhi for financial support as part Fast-Track Translational (FTT) project (MLP 0026).

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