An alternative total synthesis of diplodialide-B

Abstract

In this paper, an enantioselective synthesis of diplodialide-B has been described. To accomplish this target, a combination of regioselective ring opening of the chiral epoxide, Jacobsen hydrolytic kinetic resolution and Yamaguchi macrolactonization were used as the key steps.

Graphical Abstract

Keywords:

• Diplodialide-B
• Jacobsen hydrolytic kinetic resolution
• (R)-propylene oxide
• stereoselective synthesis
• Yamaguchi macrolactonization

Acknowledgments

The authors are thankful to CSIR-Indian Institute of Chemical Technology, Hyderabad and CSIR, New Delhi for constant encouragement in providing laboratory facilities and analytical data.