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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 49, 2019 - Issue 23
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SYNTHETIC COMMUNCATIONS REVIEWS

Selective α-bromination of aryl carbonyl compounds: prospects and challenges

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Pages 3265-3289 | Received 20 Aug 2019, Published online: 01 Oct 2019
 

Abstract

The α-bromination of carbonyl compounds is one of the most important transformations and also important precursors in synthetic organic chemistry. Particularly, the side chain monobromination of carbonyl compounds has been a challenging task, because during the reaction a small amount of disubstituted or ring brominated products as an impurity is always accompanied with monosubstituted product in the reaction mixture. In recent years substantial advances have been made for the synthesis of brominated aromatic carbonyl compounds with high selectivity. In this review, we have summarized various methods for the synthesis of α-bromo aromatic carbonyl compounds.

Graphical Abstract

Acknowledgements

S.S. thanks to Department of Science and Technology (DST), Fund for Improvement of S&T Infrastructure (FIST), Government of India for the financial support under DST FIST Program 2017 level ‘0’ (SR/FST/College – 111/2017; Dt. 16.01.2018).

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