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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 1
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ARTICLE

A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols

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Pages 112-122 | Received 01 Sep 2019, Published online: 12 Nov 2019
 

Abstract

Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.

Graphical Abstract

Acknowledgment

We are very much thankful to the Council of Scientific and Industrial Research [(CSIR), No. 02(0262)/16/EMR-II], New Delhi, for financial support and C.B.S. thank UGC for the award of a research fellowship.

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