Recent advances in development of anthelmintic agents: Synthesis and biological screening

Abstract

In recent years, the use of anthelmintic agents is increased which resulted in the development of resistance to drugs. Thus, the expansion of novel anthelmintic agents is undoubtedly and most quickly escalating area in the field of medicinal chemistry. Recent research has to provide us with a significant collection of very operative and highly selective drugs, which can kill helminthic parasites efficiently. This review article describes the survey of literature regarding the variety of synthetic methods of different heterocyclic compounds and their anthelmintic activity in the last nineteen years (2001–2019). This review is primarily addressed to the description of the recent advances in the synthesis of heterocyclic compounds as anthelmintic agents, which can facilitate the development of more potent and effective anthelmintic agents.

Graphical Abstract

Keywords:

• Anthelmintic agents
• biological activity
• helminth infestations
• heterocyclic compounds
• synthesis

Acknowledgements

The authors are thankful to the Department of Chemistry, Gujarat University, Ahmedabad, for providing the necessary facilities and also thankful to UGC-Info net & INFLIBNET Gujarat University for providing e-source facilities.