One-pot synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones using octacarbonyldicobalt as an effective CO source

Abstract

A facile one-pot protocol for the synthesis of substituted dibenzoxazepinones and pyridobenzoxazepinones from commercially available aryl/heteroaryl halides and amino phenols using octacarbonyldicobalt (Co₂(CO)₈) as an effective metal carbonyl source has been demonstrated. This method proceeds via the sequential coupling of aryl/heteroaryl halides with aminophenol by amidation and intramolecular cyclization to give dibenzoxazepinones/pyridobenzoxazepinones.

Graphical Abstract

Keywords:

• Amidation
• Co₂(CO)8
• dibenzoxazepinones
• intramolecular cyclization
• pyridobenzoxazepinones

Acknowledgements

The authors are thankful to Dr. Subhendu Kumar Mohanty, Dr. Sathya Shanker, Karthik T. Pai, and Dr. Raman Bakshi, for their help, support and encouragement throughout this work.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Kavitha is grateful to Syngene International Ltd, Bangalore, India, for financial support and the permission for higher education (Ph.D.).