Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 3
Submit an article Journal homepage
331
Views
4
CrossRef citations to date
0
Altmetric
SYNTHETIC COMMUNICATIONS REVIEWS

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

Lin ZhangDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; View further author information
,
Yu YuDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; View further author information
,
Qiang TangDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; ;Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
,
Jianyong YuanDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; ;Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, People’s Republic of ChinaView further author information
,
Dongzhi RanDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; View further author information
,
Binghua TianDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; View further author information
,
Tao PanDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; View further author information
&
Zongjie GanDepartment of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing, People’s Republic of China; ;Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
View further author information
 show all
Pages 423-431 | Received 21 Oct 2019, Published online: 17 Dec 2019
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

GRAPHICAL ABSTRACT

Additional information

Funding

We appreciate the finical support from the National Natural Science Foundation of China [No. 21907013] and the Scientific and Technological Research Program of Chongqing Municipal Education Commission (KJQN20190043).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.