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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 6
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ARTICLES

Decarboxylation of indole-3-carboxylic acids under metal-free conditions

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Pages 805-812 | Received 26 Oct 2019, Published online: 14 Feb 2020
 

Abstract

Two reaction systems have been developed for the decarboxylation of indole-3-carboxylic acids. The decarboxylation can be achieved smoothly under K2CO3-catalyzed or acetonitrile-promoted basic conditions. It provided an efficient and simple method for the transformation of indole-3-carboxylic acids and the corresponding indoles were isolated with good to excellent yields. From the experimental facts, we put forward the possible reaction mechanism.

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Additional information

Funding

The work was supported by the Natural Science Foundation of Guizhou Province [Grant No. qiankehejichu [2018] number 1141], the Science and Technology Foundation Project of Liupanshui [Grant No. 52020-2018-04-10] and National Natural Science Foundation of China [No. 21763017].

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