Synthesis of spirooxindole analogues from 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde

Abstract

A series of spirooxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from isatin and sarcosine or L-proline with the dipolarophile (E)-3-(2-cyclopropyl-5-(4-fluorophenyl) quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives. The stereochemistry of the cycloadducts was assigned based on the single-crystal X-ray.

GRAPHICAL ABSTRACT

Keywords:

• Azomethine
• cycloaddition
• isatin
• quinoline-3-carbaldehyde
• sarcosine
• spirooxindoles

Additional information

Funding

The author Gorli Venkata Nookaapparao thanks Dr. Raghu Palle, BIOCON limited, Bangalore, India and The Director, CSIR-Central Leather Research Institute, Adyar, Chennai - 600 020, India for the research funding support.