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Abstract
The selective aza-Michael addition at N1-position of indoles to 2-arylidenemalononitriles in the presence of potassium hydroxide is described. The salient features of this protocol are no transition-metal catalysts, mild conditions, high chemoselectivity, high atom economy, high yield and simple work-up procedures.
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Funding
The authors thank the National Natural Science Foundation of China [21462038] for the financial support of this work.