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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 6
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ARTICLES

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

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Pages 813-822 | Received 12 Oct 2019, Published online: 13 Jan 2020
 

Abstract

A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.

GRAPHICAL ABSTRACT

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under Grant [No. 81502917].

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