Electrochemical oxidative iodination of imidazo[1,2-a]pyridines using NaI as iodine source

Abstract

An electrochemical oxidative iodination of imidazo[1,2-a]pyridines is achieved in this study. This reaction utilizes NaI as an iodine source and a supporting electrolyte under metal-free and exogenous chemical oxidant-free reaction conditions. The present protocol provides an efficient route to prepare 3-iodoimidazo[1,2-a]pyridines derivatives.

Graphical Abstract

Keywords:

• Electrochemical oxidation
• imidazo[12-a]pyridines
• iodination
• 3-iodoimidazo[1,2-a]pyridines

Additional information

Funding

This research was supported by Soonchunhyang University Research Fund and Basic Science Research Program through the National Research Foundation of Korea [NRF-2019R1F1A1059821].