A one-pot three-step multicomponent synthesis of functionalized allyl dithiocarbamates using Baylis–Hillman reaction

Abstract

A one-pot, pseudo five-component, highly diastereoselective, and mild procedure for the synthesis of functionalized allyl dithiocarbamates is developed. The Baylis–Hillman (BH) reaction of aromatic (heteroaromatic) aldehydes and activated alkenes using DABCO, followed by acetylation of BH adducts with acetic anhydride in the presence of a catalytic amount of DMAP, and nucleophilic substitution reaction by in situ prepared dithiocarbamates from amines and CS₂ are three steps of this protocol.

Graphical Abstract

Keywords:

• Allyl dithiocarbamates
• Baylis–Hillman reaction
• carbon disulfide
• multicomponent reactions

Acknowledgments

We thank the research council of Kharazmi University for supporting this work.