Microwave accelerated azomethine ylide cycloaddition with Baylis–Hillman adducts

Abstract

Azomethine ylides generated in situ from isatins and α-amino acids undergo smooth 1,3-dipolar cycloaddition with olefins derived from the Baylis–Hillman reaction to produce fused 2-quinolinone derivatives in good yields with high selectivity. The use of microwave irradiation makes this method quite simple and rapid to generate polycyclic frameworks in a single step.

Graphical Abstract

Keywords:

• Amino acids
• azomethine ylides
• cycloaddition
• fused heterocycles
• isatins

Acknowledgments

K.N.R. thanks UGC New Delhi for the award of a fellowship (IICT/Pubs./2019/228).

Author contributions

The manuscript was prepared by the contribution of all authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.