Facile one-pot multicomponent synthesis of highly functionalized tetrahydropyridines using thiamine hydrochloride as an organocatalyst

Abstract

Thiamine hydrochloride (VitB₁) has been found to be an efficient catalyst for the multicomponent synthesis of highly functionalized tetrahydropyridines from the reaction of β-ketoester, aromatic aldehydes and anilines. VitB₁ is easily available, cheap, and eco benign.

Graphical Abstract

Keywords:

• β-Ketoester
• tetrahydropyridine multicomponent
• thiamine hydrochloride
• VitB₁

Acknowledgments

The authors are thankful to Department of Chemistry, University of Jammu for providing all necessary facilities.

Additional information

Funding

The authors are thankful to University Grant Commission, New Delhi for Junior research fellowship (S.S), Department of Science and Technology, Government of India, New Delhi for INSPIRE fellowship (A.G) and NMR facility under PURSE.