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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 10
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SYNTHETIC COMMUNICATIONS REVIEWS

PEG-assisted one-pot three-component synthesis of 1,3-oxazino quinoline and chromeno 1,3-oxazin derivatives under catalyst free condition

, , , & ORCID Icon
Pages 1456-1467 | Received 15 Oct 2019, Published online: 16 Mar 2020
 

Abstract

A straightforward and greener PEG-assisted protocol has been disclosed for the cascade synthesis of [1,3]Oxazino quinoline, and chromeno[1,3]oxazin derivatives via three component reaction of multifarious aromatic amines with formaldehyde and 4-hydroxyquinoline-2(1H)-one or 4-methylumbelliferone by using very convenient reaction conditions. This methodology represents a sustainable approach for rapid access to a library of diversity oriented highly pure [1,3]oxazino scaffolds with broad substrate scope.

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Additional information

Funding

This work was supported by a research grant of Pukyong National University (2019).

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