Enantiospecific formal total synthesis of (+)-dihydrokawain-5-ol

Abstract

Formal total synthesis of dihydrokawain-5-ol is accomplished starting from tartaric acid. Key reactions include Horner–Wadsworth–Emmons olefination, sodium borohydride mediated stereoselective reduction, orthogonal protection and deprotection of alcohols and ring closing metathesis.

Graphical Abstract

Keywords:

• Biological activities
• metathesis
• natural products
• total synthesis

Acknowledgments

P.K.M thanks the University Grants Commission (UGC), New Delhi for a senior research fellowship and also his research mentor Prof. K. R. Prasad for the encouragement and helpful discussion.

Additional information

Funding

This work was financially supported by University Grants Commission (UGC), New Delhi.