Abstract
A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH3CN under mild conditions. Neutral conditions, atom economy, easy work-up procedures and compatible with different functional groups are the salient features of this protocol.
Graphical Abstract
Acknowledgments
One of the authors (N.R.) thanks Council of Scientific and Industrial Research (CSIR), New Delhi, for financial support.