A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions^†

D. Subhas BoseOrganic and Biomolecular Chemistry Division, Department of Energy and Environmental Engineering, Fine Chemicals Lab, CSIR-Indian Institute of Chemical Technology, Hyderabad, IndiaCorrespondence[email protected]

Nukala RameshOrganic and Biomolecular Chemistry Division, Department of Energy and Environmental Engineering, Fine Chemicals Lab, CSIR-Indian Institute of Chemical Technology, Hyderabad, India

Abstract

A new and practical method has been developed for the synthesis of 2,4-disubstituted quinolines via one-pot three-component reaction of o-amino arylketones, aldehydes and ammonium acetate in high yields by using DDQ in CH₃CN under mild conditions. Neutral conditions, atom economy, easy work-up procedures and compatible with different functional groups are the salient features of this protocol.

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Acknowledgments

One of the authors (N.R.) thanks Council of Scientific and Industrial Research (CSIR), New Delhi, for financial support.

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A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions^†

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A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions†

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A convenient access to 2,4-disubstituted quinazolines via one-pot three-component reaction under mild conditions^†