Synthesis of halogenated 1-O-alkylglycerols from ricinoleic acid derivatives

Abstract

Resistance to the existing drugs and increasing numbers of diseases result in identifying new drug candidates with new forms of activity. As marine organisms are well known to provide a wide range of original compounds, Herein, we report the synthesis of new non-natural brominated, iodinated and chlorinated-substituted 1-O-alkylglycerols 5–7, analogs of a prominent 1-O-alkylglycerol (AKG) of the natural shark liver oil (SLO) mixture, namely the AKGs 18:1, n-9.

Graphical Abstract

Keywords:

• Alkylglycerol (AKG)
• fatty acids
• halogenated compounds
• lipids
• marine natural products

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Acknowledgments

We thank the Agence Universitaire de la Francophonie, Région de Bretagne, CNRS (UMR 6226) and the Université de Rennes 1 for their financial support. We also thank the CRMPO (Center Régional de Mesures Physiques de l’Ouest, Rennes, France) for HRMS spectra and microanalyses.

Disclosure statement

The authors declare no conflict of interest.