Abstract
A series of new flavanone-triazole hybrids (7a–m) were synthesized from flavanone oximes (6a–c) via multistep synthetic strategy, involving Cu (I) catalyzed azide, alkyne 1,3-dipolar cycloaddition by Click reaction. All the synthesized compounds were tested for their cytotoxicity against HCT-15, HeLa, NCI-H522, and HEK-293 (normal cell line) cell lines. Compounds 6a, 7a, 7b, 7d, 7e, 7j, and 7m showed the significant cytotoxicity, wherein compound 7b showed potential cytotoxicity against NCI-H522 cell line and compounds 6a and 7a were offensive with HEK-293 in their toxicity profile.
Graphical Abstract
![](/cms/asset/4779a51b-1a47-4a69-b59f-dd343ed990ef/lsyc_a_1759645_uf0001_c.jpg)
Acknowledgments
GM thanks to the UGC-New Delhi, India, for providing Senior Research fellowship, Head Department of Chemistry and CFRD, Osmania University, Hyderabad, India for providing laboratory facilities and spectral data.