Heterogeneous gold(I)-catalyzed three-component reaction of aldehydes, alkynes, and orthoformates toward propargyl ethers

Abstract

A novel and efficient heterogeneous gold(I)-catalyzed three-component reaction of aldehydes, alkynes, and orthoformates has been developed that proceeds smoothly in dichloroethane (DCE) at 83 °C in the presence of 5 mol% magnetic nanoparticles-anchored phosphine gold(I) complex (Fe₃O₄@SiO₂-P-AuOTf) and offers a general and practical approach for the preparation of a variety of propargyl ethers with good yields. This heterogeneous gold(I) catalyst can be facilely recovered by simply applying an external magnetic field and recycled at least eight times without any apparent decrease in the catalytic efficiency.

Graphical Abstract

Keywords:

• Gold
• heterogeneous catalysis
• magnetic nanoparticles
• propargyl ether
• three-component reaction

Additional information

Funding

We thank the National Natural Science Foundation of China [No. 21462021], the Natural Science Foundation of Jiangxi Province of China [No. 20161BAB203086] and Key Laboratory of Functional Small Organic Molecule, Ministry of Education [No. KLFS-KF-201704] for financial support.