Synthesis and structure of pyrido[1,2-a]quinazoline condensed derivatives

Abstract

Present manuscript describes the synthesis and molecular structure features of novel condensed pyrido[1,2-a]quinazolines. The above-mentioned compounds were synthesized via condensation of 2-[azolyl-(аzinyl-)]anilines with 5-oxohexanoic acid. The tandem condensation intermediates were isolated and cyclized under various conditions. The structures of synthesized compounds were confirmed by LC-MS and NMR-spectroscopy. The existence of the substituted pyrido[1,2-a][1,2,4]triazolo[1,5-c]quinazolines molecules as superposition of two resonance structures was detected by the X-Ray analysis.

Graphical Abstract

Keywords:

• 2-[Azolyl-(azinyl-)]anilines
• polycyclic heterocycles
• pyrido[1,2-a]quinazolines
• tandem reaction
• X-ray study

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors gratefully acknowledge Enamine Ltd. (Kiev, Ukraine) for financial support of this work.