Efficient synthesis of some pyrimidine and thiazolidine derivatives bearing quinoline scaffold under microwave irradiation

Abstract

An efficient and facile approach for the synthesis of new quinoline derivatives was accomplished via reactions of 2-chloroquinoline-3-carbaldehyde with active methylene compounds, for example, 1,3-dimethylbarbituric acid, thiobarbituric acid and 2,4-dioxothiazolidine and aromatic amines through one-pot multi-component reaction (MCR) as sources of pyrimidine and thiazolidine derivatives bearing quinoline moiety. All compounds were synthesized via conventional and Microwave Irradiation conditions. The best results (short reaction times, pure products, high yield) were obtained by microwave irradiation. The synthesized derivatives were characterized by various physicochemical and spectral techniques from their analytical and spectral data.

Graphical Abstract

Keywords:

• Green chemistry
• quinoline
• pyrimidines
• thiazolidine
• ultraviolet

Acknowledgments

Technical support from the Chemistry Department, Faculty of Science, Ain Shams University is gratefully acknowledged. Our special thanks are extended to Prof. Khaled A. M. Abouzid, from Faculty of Pharmacy, the University of Sadat City for his guidance, moral supports, encouragements, and valuable criticism.

Disclosure statement

The authors declare no conflict of interest.