Abstract
N-acyliminium reagents formed in situ from benzothiazole and alkyl chloroformates react with hydroxyarenes in a Friedel-Crafts manner, providing access to 2-(hydroxyaryl)-benzothiazolines with antibacterial properties.
Graphical Abstract
Acknowledgement
The authors are grateful to the Faculty of Biology, Department of Plant Physiology and Molecular Biology and Dr. Mladen Naydenov for carrying out high resolution mass spectral measurements on equipment provided under the EC FP7/REGPOT-2009-1/BioSupport project.