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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 20
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Articles

Polyphosphoric acid-promoted synthesis of coumarins lacking substituents at positions 3 and 4

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Pages 3080-3085 | Received 26 Apr 2020, Published online: 20 Jul 2020
 

Abstract

Coumarins have recently emerged as a hot topic of research due to their diverse pharmacological properties. This work described a method for the synthesis of 3,4-diunsubstituted coumarins promoted by polyphosphoric acid (PPA) from salicylaldehydes and acetic anhydride. Various coumarins were produced in good to excellent yields.

Graphical Abstract

Acknowledgment

The authors are grateful for the help provided by the staff at the Key Laboratory of Chemistry for Natural Products of Guizhou Province and the Chinese Academy of Sciences.

Additional information

Funding

The work here was supported by the National Natural Science Foundation of China [No. 81860609], the Guizhou Provincial Natural Science Foundation [No. QKHJC[2019]1213], the High-level Innovative Talents Training in Guizhou Province [No. 2015-4027] and the Project of Guizhou Science and Technology Platform and Talent Team Under Grant [No. QKHPTRC[2017]5614].

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