A facile access for the synthesis of 1-hetero(aryl)-1,2,3-triazoles linked to equol under mild conditions

Abstract

We herein report a convenient methodology for the synthesis of 1-hetero(aryl)-1,2,3-triazoles linked with equol by utilizing copper-catalyzed azide-alkyne cycloaddition reaction under exceptionally mild conditions. The salient features of this developed protocol include: easy isolation process, good to excellent yield of the products and appendage diversity of heteroaryl triazoles.

Graphical Abstract

Keywords:

• Copper
• cycloaddition
• equol
• 1,2,3-triazole

Additional information

Funding

The authors are thankful to Russian Science Foundation [Grant # 18-13-00161].