Glycinamide hydrochloride as a transient directing group: Synthesis of 2-benzylbenzaldehydes by C(sp³)−H arylation

Abstract

Glycinamide hydrochloride as an inexpensive and commercially available transient directing group for the C(sp³)−H arylation of 2-methylbenzaldehydes is described. A series of practical 2-benzylbenzaldehydes bearing various functional groups are efficiently synthesized in satisfactory yield by this strategy. This method can also be extended to gram scale.

Graphical Abstract

Keywords:

• Transient directing group
• 2-benzylbenzaldehyde
• glycinamide hydrochloride
• C(sp³)−H arylation
• 2-methylbenzaldehyde

Additional information

Funding

The authors thank the National Natural Science Foundation of China [21462038] for the financial support of this work.