L-Proline based ionic liquid: A highly efficient and homogenous catalyst for synthesis of 5-benzylidene-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione and pyrano[2,3-d] pyrimidine diones under ultrasonic irradiation

Abstract

A catalytic, practical, efficient procedure for the synthesis of 5-benzylidene-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione and pyrano[2,3-d] pyrimidine diones at room temperature was developed using L-Proline nitrate ionic liquid under ultrasonic irradiation. The L-Proline nitrate is homogeneous and green catalyst easy to prepare by mixing L-Proline and nitric acid possess excellent catalytic activity under standard ultrasonic bath at room temperature for the synthesis of pyrimidine core. This adequate procedure offers some advantages like the use of green solvent H₂O, environmentally green benign procedure, excellent yields, simple procedure, short reaction times, no need for column chromatographic separation and reusability of catalyst for five subsequent reaction.

Graphical Abstract

Keywords:

• Amino acid ionic liquid
• e5-benzylidene-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
• L-Proline nitrate
• pyrano[2,3-d] pyrimidine diones
• ultrasonic irradiation

Acknowledgments

The authors are thankful to BCUD K.B.C.N.M.U Jalgaon for providing financial support. We also gratefully acknowledgment to School of Chemical Science K.B.C.N.M.U Jalgaon for providing all necessary facilities.

Disclosure statement

The authors declare no competing financial interest.

Additional information

Funding

This work was supported by Board of College and University Development, K.B.C.N.M.U. Jalgaon.