A simple and highly efficient synthesis of novel fluorinated 4,6-disubstituted aminopyrimidines using Cd(OAc)₂

Abstract

A highly efficient fluorination reaction of 4,6-disubstituted aminopyrimidines using N-Fluorobenzenesulfonimide (NFSI) has been developed, presumably proceeding via C–H bond activation. Cadmium acetate was employed as the salts, and various fluorinated 4,6-disubstituted aminopyrimidines have been generated in good to excellent yields. This chemistry endows an economical method of valuable fluorinated 4,6-disubstituted aminopyrimidines through a direct C–F bond formation.

Graphical Abstract

Keywords:

• NFSI
• fluorination
• aminopyrimidine
• C–F bond
• cadmium acetate

Acknowledgments

The authors are thankful to USIC, University of Delhi, for providing instrumentation facilities. PK and AK are thankful to CSIR for SRF, respectively.

Additional information

Funding

The authors are thankful to SERB, Department of Science and Technology, India, for providing financial support.