Synthetic routes to rhodanine scaffolds

Abstract

Rhodanine structural scaffolds are an important class of sulfur-containing heterocycles with a broad spectrum of applications in medicinal chemistry. Highly functionalized piperidine scaffolds have shown profound impact in drug discovery research owing to its important bioactivity. The green and high-yielding synthesis of rhodanine structural scaffolds from readily available materials remains is a hot topic research for the synthetic chemistry community. In this review, we discuss the recent various synthetic procedures reported in the literature for the synthesis of rhodanine structural scaffolds.

Graphical Abstract

Examples of biologically active rhodanine derivatives.

Keywords:

• Medicinal chemistry
• rhodanine structural scaffolds
• S-heterocycles
• synthetic chemistry