Abstract
Allyl pyridyl ethers are important intermediates in organic synthesis, which could be accessed by Williamson or SNAr-type etherification. While Williamson etherification has been well studied, the SNAr-type reaction remains less explored. In this paper, a series of allyl pyridyl ethers were synthesized via transition metal-free SNAr-type etherification with different allyl alcohols in good yields. The poor-yielding etherification for cinnamyl alcohol was finally optimized to 82% yield with a molecular sieve as the additive.
Graphical Abstract
Acknowledgments
The authors thank the Yanshan University High-end Talents Project: No. BL18014 and the Department of Education of Hebei Province Foundation: No. QN2019220.