Part–I: Utilities of active methylene compounds and heterocycles bearing active methyl or having an active methine in the formation of bioactive heteroarylpyrimidines and pyrimidopyrimidines

Abstract

Common and novel synthesized active methylene compounds as well as heterocycles having active methyl or active methine sites have been used for the synthesis of a wide variety of substituted pyrimidines and pyrimidopyrimidines of interesting medical and pharmaceutical importance. Many synthetic approaches were used for the preparation of target heterocyclic systems such as cyclocondensation reactions, ring-opening ring-closure, cycloaddition, acid-, base-catalyzed reaction, intramolecular cyclization and self-condensation has been reported in this part. Also, three different biological applications namely, antimicrobial activity, cellobiase activity and mollucicidal activities was carried out on some reported pyrimidines and pyrimidopyrimidines.

Graphical Abstract

Keywords:

• Active methylene
• biological importance
• pyrimidopyrimidines
• substituted pyrimidines