Carbostyril derivatives: Synthesis of novel carbostyril-3′-carbonitrilselenophene hybrid compounds and investigation of their antiproliferative properties on prostate and breast cancer

Abstract

To synthesize a new series of carbostyril-3′-carbonitrilselenophene hybrid compounds, Pechmann coumarin compounds were reacted with 2-amino-3′-carbonitrilselenophene derivatives and their anticancer activities on MCF7 and DU145 cell lines and antioxidant activities were investigated. Anticancer and antioxidant activities of the starting compounds and their corresponding new hybrid compounds were compared. It was determined that IC₅₀ values of hybrid compounds (3e, 3f, 3g, and 3h) on the MCF7 breast cancer cell line showed the highest cytotoxic activity with 7.99, 3.64, 7.72, and 2.74 µM values, respectively. In the case of anticancer activity on the DU145 prostate cancer cell line, compounds 3f and 3h were found to have the highest cytotoxic activity with IC₅₀ values of 4.21 and 3.90 µM, respectively. The compound 3g is also the most radical scavenging compound with an inhibition value of 88.78%.

GRAPHICAL ABSTRACT

Keywords:

• Anticancer activity
• azacoumarin
• breast cancer
• carbostyrils
• heterocycles
• prostate cancer
• selenophene

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article [and/or] its supplementary materials.

Additional information

Funding

The present work was financially supported by the Scientific and Technical Research Council of Turkey (TUBITAK) through a scholarship to Mehmet Erşatır and by the Scientific Research Committee of Cukurova University [FDK-2017-8591].