Convenient one-step synthesis of quinoline-3,4-dicarboxylate derivatives

Abstract

Herein a practical and convenient procedure for the one-step synthesis of quinoline-3,4-dicarboxylate derivatives from isatins and β-keto esters in alcohols by sulfuric acid-catalyzed was described. This novel protocol offers the advantages of high conversion rates, short reaction times, and easy handling.

Graphical Abstract

Keywords:

• Isatins
• β-keto esters
• quinoline-3,4-dicarboxylate derivatives
• sulfuric acid

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [81172927 and 81573297].