SnCl₂⋅2H₂O catalyzed one-pot three components synthesis of pyrano[4,3-b]chromenes and chromeno[4,3-b]chromenes

Abstract

A new green method has been presented for the synthesis of some novel derivatives pyrano[4,3-b]chromenes and chromeno[4,3-b]chromenes based on bio-mass triacetic acid lactone or 4-hydroxycoumarine via a one-pot three components condensation reaction of triacetic acid lactone, dimedone, and an aromatic aldehyde using SnCl₂.2H₂O as a catalyst in ethanol at 60 °C. Several activated and deactivated aromatic aldehydes were selected to afford the products in high to excellent yields. Advantages of these syntheses are operational simplicity, mild reaction conditions, environmentally friendly and easy workup.

Graphical Abstract

Keywords:

• [43-b]Chromene
• 4-hydroxycoumarine
• multicomponent reaction
• triacetic acid lactone
• tin (II) chloride

Additional information

Funding

The author is grateful for the financial support provided by the Kharazmi University.