Heterogeneous gold(I)-catalyzed hydroamination of allenamides with arylamines toward allylamino E-enamides

Abstract

A novel and highly efficient heterogeneous gold(I)-catalyzed hydroamination of allenamides with arylamines has been developed that proceeds effectively under mild conditions and offers a general and practical route for the synthesis of allylamino E-enamides with good to excellent yields and high stereoselectivity. The supported gold(I) catalyst can be reused at least seven times without any apparent decrease in the catalytic activity.

Graphical Abstract

Keywords:

• Gold
• hydroamination
• enamide
• allenamide
• heterogeneous catalysis

Additional information

Funding

The authors thank the National Natural Science Foundation of China [No. 21462021], the Project of Education Department of Jiangxi Province [No. GJJ202306, JY20223] and Key Laboratory of Functional Small Organic Molecule, Ministry of Education [No. KLFS-KF-201704] for financial support.