Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

Pawan K. Sharmaa Department of Chemistry, Kurukshetra University, Kurukshetra, IndiaCorrespondence[email protected]

Rajiv Kumara Department of Chemistry, Kurukshetra University, Kurukshetra, India;b Ch. Mani Ram Godara Government College for Women, Fatehabad, India

Sita Rama Department of Chemistry, Kurukshetra University, Kurukshetra, India;c Department of Chemistry, J. C. Bose University of Science & Technology, YMCA, Faridabad, India

Navneet Chandaka Department of Chemistry, Kurukshetra University, Kurukshetra, India

Abstract

A one pot synthesis of β-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for β-ketonitriles.

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Acknowledgments

One of the authors (Rajiv Kumar) is thankful to University Grants Commission, New Delhi, India for the providing JRF/SRF. HRMS facility of Materials Research Centre, MNIT Jaipur, India is gratefully acknowledged.

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No potential conflict of interest was reported by the author(s).

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Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

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Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

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